The San Francisco Giants (19-10) and the San Diego Padres (17-11) open a 2-game set Tuesday at Petco Park. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Padres won 7-6 last year
The Giants are coming off a 2-1 series win vs. the Texas Rangers in San Francisco, wrapping up the set with a 3-2 victory as -132 favorites Sunday with the Under (7.5) cashing. LF Heliot Ramos walked off Sunday’s finale with a Little League home run in the ninth inning — officially scored as an infield single and 2 Texas errors. Rangers RP Luke Jackson sparked the chaos with a wide throw to first base, and 1B Jake Burger followed with an errant throw to third after fielding the ball in foul territory, allowing Ramos to score.
The Padres were swept by the Tampa Bay Rays in a 3-game home set, which concluded with a 4-2 loss as +109 underdogs Sunday with the Under (8.5) hitting. San Diego was swept for the first time this year. After starting the season 15-4, it has lost 7 of its last 9 games, including a current season-high 4 straight.
Giants at Padres projected starters
RHP Logan Webb vs. RHP Nick Pivetta
Webb (3-1, 1.98 ERA) makes his seventh start. He has a 1.10 WHIP, 2.5 BB/9 and 10.9 K/9 through 36 1/3 innings.
- Last start: Win, 6 1/3 IP, 0 ER, 6 H, 3 BB, 6 K in 4-2 home victory vs. Milwaukee Brewers Wednesday
- 2025 road stats: 2-1, 3.13 ERA (23 IP, 8 ER), 20 H, 7 BB, 28 K in 4 starts
- 2024 vs. Padres: 1-1, 3.91 ERA (23 IP, 10 ER), 32 H, 5 BB, 15 K in 4 starts
- Career vs. Padres: 4-3, 2.90 ERA (80 2/3 IP, 26 ER), 1.23 WHIP, 7.3 K/9 in 13 starts and 1 relief appearance
Pivetta (4-1, 1.20 ERA) makes his sixth start. He has a 0.77 WHIP, 2.1 BB/9 and 9.0 K/9 through 30 innings.
- Last start: Win, 7 IP, 0 ER, 2 H, 2 BB, 6 K in 2-0 shutout at Detroit Tigers April 22
- 2025 home stats: 3-0, 0.45 ERA (20 IP, 1 ER), 8 H, 2 BB, 20 K in 3 starts
- Career vs. Giants: 1-1, 5.40 ERA (13 1/3 IP, 8 ER), 17 H, 8 BB, 15 K in 2 starts and 3 relief appearances — last faced them in 2019
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Giants at Padres odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:55 p.m. ET.
- Moneyline (ML): Giants -135 (bet $135 to win $100) | Padres +110 (bet $100 to win $110)
- Run line (RL)/Against the spread (ATS): Giants -1.5 (+140) | Padres +1.5 (-170)
- Over/Under (O/U): 7 (O: +105 | U: -125)
Giants at Padres picks and predictions
Prediction
Padres 3, Giants 2
Moneyline
Though it’s on a season-high 4-game skid, SAN DIEGO (+110) getting plus odds with Pivetta on the mound at home seems too good to pass up. Pivetta has allowed just 1 earned run in 20 innings at Petco Park, and the Padres have gone 3-0 in his 3 home starts this year.
Webb has been impressive as well, allowing a total of 1 earned over his last 2 starts, but the Giants have gone just 2-2 over his last 4 outings.
BET PADRES (+110).
Run line/Against the spread
Taking Padres +1.5 (-170) isn’t a bad bet, but getting the plus odds on their ML is the preferred play.
PASS on a spread wager.
Over/Under
Pivetta has held opponents to 1 earned run or fewer in 4 of his 5 starts this season, while Webb has done the same in 4 of his last 5. Offensively, the Giants have been held to 3 runs or fewer in 3 straight games, and the Padres have scored 2 or fewer in 5 consecutive contests.
BET UNDER 7 (-125).
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