Guardians vs. Twins Prediction, Odds, Picks - April 29

Data Skrive

Jose Ramirez and the Cleveland Guardians will square off against Byron Keiron Buxton and the Minnesota Twins at Progressive Field in the first of a four-game series, Tuesday at 6:10 p.m. ET. The Twins are +128 moneyline underdogs for this matchup against the favorite Guardians (-153). Cleveland is the run-line favorite (-1.5). The matchup’s over/under is set at 8 runs.

Check out everything you need to know from a betting perspective on the Guardians-Twins game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best moments between the Boston Red Sox and the Cleveland Guardians.

Guardians vs. Twins Game Information & Odds

When: Tuesday, April 29, 2025 at 6:10 p.m. ET
Where: Progressive Field in Cleveland, Ohio
How to watch on TV: CLEG and MNNT

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Guardians -153 +128 8 -108 -112 -1.5 +145 -173

Guardians vs. Twins Prediction

Score Prediction: Guardians 5, Twins 4
Total Prediction: Over 8 runs
Win Probabilities: Guardians 51%, Twins 49%

Guardians vs. Twins Betting Insights

This season, the Guardians have been favored 10 times and won eight of those games.
Cleveland has entered three games this season favored by -153 or more, and won each of those games.
Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 60.5% chance to win.
The Twins have been victorious in one of the seven contests they have been chosen as underdogs in this season.
Minnesota has played as an underdog of +128 or more just one time this year and came away with a loss in that game.
Bookmakers have implied with the moneyline set for this matchup that the Twins have a 43.9% chance of pulling out a win.

Guardians Recent Betting Performance

In the last 10 games, the Guardians have been listed as the moneyline favorite by oddsmakers just twice, and they won both games.
Over their last 10 matchups (all had set totals), the Guardians combined with their opponents to go over the run total six times.
The Guardians’ ATS record is 5-5-0 over their past 10 games.

Guardians Recent Stats

Stat Avg/Total Record 6-4 Runs Per Game 4.1 HR 10 ERA 5.10 K/9 9.1

Guardians Player Insights

Steven Kwan paces the Guardians with a .346 batting average.
Kwan is 57th in home runs and 46th in RBI among all hitters in MLB.
Kwan takes a hitting streak of 10 games into this matchup. In his last 10 games he is batting .400 with four doubles, a home run, three walks and four RBI.
Ramirez is batting .263 with four doubles, five home runs and nine walks.
Ramirez is 36th in homers in the majors, and 61st in RBI.
Kyle Manzardo has a team-high seven home runs and 18 runs batted in.
Gabriel Arias is hitting .272 with five doubles, four home runs and five walks.
Arias is riding a three-game hitting streak into this one. In his last five games he is hitting .250 with two doubles and an RBI.

Twins Recent Betting Performance

The Twins have played as underdogs in three of their past 10 games and lost each of those contests.
In their last 10 games with a total, the Twins and their opponents have failed to hit the over seven times.
The Twins have won six of their last 10 games against the spread.

Twins Recent Stats

Stat Avg/Total Record 6-4 Runs Per Game 4.4 HR 8 ERA 3.35 K/9 10.0

Twins Player Insights

Buxton leads the lineup with a batting average of .237, while pacing the Twins in home runs, with six and runs batted in with 15.
Among all hitters in MLB, Buxton ranks 24th in home runs and 46th in RBI.
Trevor Larnach is batting .234 with two doubles, four home runs and 13 walks.
Larnach is 57th in home runs and 61st in RBI among all MLB batters this season.
Ty France leads the Twins with 15 runs batted in while recording a team-high batting average of .237.
Carlos Javier Correa has seven doubles, a home run and seven walks while hitting .211.

Check out the best moments between the Boston Red Sox and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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